The film takes place in March of 2020 right as COVID-19 starts to be a major threat to the U.S. and places start to shut down and people start to panic. Meanwhile, Cynthia (Lixy Lestat), who is on the run after she steals money from her former boss who is a drug lord. As she drives across country she comes down with COVID. She pulls over to a motel to get some rest when she meets Willow (Sushii Xyhyvette Holder), who is a mysterious woman. Willow takes care of Cynthia when she passes out in the motel parking lot. Cynthia learns that Willow is not just a normal woman but has a thirst for blood and she claims to be a vampire.