The Global Guardian Force deals with extraterrestrial attacks on Earth. Gento leads SKaRD, using robot Earth Garon against Kaiju. Gento investigates Ultraman, has memories of a blazar.

A wave of kaiju emerges from an industrial area in Tokyo, prompting Captain Gento and the Special Kaiju Reaction Detachment (SKaRD) to engage in the relentless battle. Yet despite their efforts, the endless kaiju attack continues. Suspecting a link to Necromass Co., an advanced chemical company that researches kaiju carcasses and owns factories in the industrial area where the monsters came from, SKaRD rushes to the company's CEO and renowned chemist, Dr. Mabuse. At Necromass Co.'s research facility, Dr. Mabuse explains the development of the damudoxin, a substance on the brink of achieving immortality. Meanwhile, Alien Damuno, who claims themselves as the "ruler of the universe" appears. Chaos ensues when damudoxin leaks from the destroyed tanks, consuming samples of kaiju carcasses and giving rise to the giant Gongilgan, the Demonic Carcass. Set in Tokyo, the capital of Japan, Ultraman Blazar and SKaRD clash in a showdown against the giant kaiju!.