As detective Guthrie Hayward spirals through a labyrinth of vice and deceit, his unconventional allies include a loyal dingo accountant, his drug-addled siblings, and an enigmatic Mennonite with possibly mystical abilities. With danger lurking at every corner and a cryptic conspiracy pushing society to its limits, Guthrie must navigate treacherous waters to crack the case and make a clean getaway.

In this campy screwball comedy, environmentalist Larry takes an experimental virility drug to woo back his wife Mary who's having an affair with Barry who works for Thierry who plans to destroy the remaining habitat of the endangered pocket mouse. Larry and Barry both take a double dose of the virility drug and when it makes them gay their entire world view changes. Barry resists and attempts ridiculous 'conversion' treatments; Larry discovers the joys of being a gay man. They both get what they want in the end.

No longer a prisoner of The Master or the primal god Manos, Debbie hunts down monsters with her team of survivors and misfits.