Orpheus wakes to discover a priceless Caravaggio painting stolen from St. John's Cathedral in Valletta while under his watch. With the city on edge, a detective is brought in from Washington to aid the local police in solving the case.

Two women—Diana, a flamboyant and ruthless thief, and Evie, a seemingly innocent young woman with a troubled past—become embroiled in a series of horrific murders on the island of Malta.