In a not so distant future, great white sharks have gone extinct. When a mad scientist plays god and genetically engineers a shark/human, he unleashes the highly viral monster on the unsuspecting citizens of a nearby small town.

A rather hapless dude buys a backpack at a garage sale. When people around him turn up dead, he comes to believe his new accessory may be to blame. Tracking its history, he discovers it has connections back to a haunted house in a small town called Amityville...