Inspired by Sir Arthur Conan Doyle's classic literary characters, the series follows Dr. Wato-san Tachibana and Sara Shelly "Sherlock" Futaba, an eccentric police consultant who uses deduction to solve strange cases in modern-day Japan.

After the appearance of a new Gojira (Godzilla), the Japanese government builds a robotic Godzilla from the bones of the original monster that attacked Tokyo in 1954 to stop the beast.