Moon River takes place in Glendale, California and follows the story of Richard Waters and his film crew. On the night of their first day of filming, Richard and his team throw a party where their production assistant, Peter, is murdered. After another murder, the people of Glendale, as well as the police, conclude Richard must be the one behind the murders. It's up to Richard to solve the case before he finds himself killed or in prison.

Following the sudden and traumatic loss of his family in the early days of a virulent plague, Carter retreats into the desert, hiding away from what remains of the world. But when a lost girl arrives at his door seeking help, he must confront old wounds and find a way to finally heal... Or bleed out.