Pork butcher stall lady boss Chu Ying-kiu (Katy Kung) has innate mystical power. But she is inflicted with some strange illness that causes her to grow a beard. She hopes to find the elixir mentioned in Sutra of Forty-two Chapters for treating her illness. Over the years, university Chinese language professor Cheung King (Moses Chan) has been passionate about finding this legendary treasure. However, he has been suffering from insomnia as he was devastated in an incident. Math genius Siu Kwai-chi (Kamen Kong) is clever and smart. She falls in love at first sight with A&E male nurse Orr Kin-ning (Kalok Chow). Kwai-chi is torn between good and evil. And she really wants to find the treasure as she hopes to become an overnight millionaire. Fate brings Cheung King, Ying-kiu and Kwai-chi together. They come up with all kinds of schemes as they each want to snatch the treasure. While they compete with each other, a war on the human conscience's immorality and righteousness has started. And it is a life-and -death struggle .

During Emperor Renzong's reign in the Song Dynasty, Bao Zheng is appointed Kaifeng Prefecture Prefect. Bao Zheng, his trusted aide Gongsun Ce, Guard Zhan Zhao, and the four Constables are determined to crack down on corrupt dealings. Merchant's daughter Yun Qianyu is an eloquent speaker. Under Gongsun Ce's guaidance, she eventually becomes a consel. Ji Niannian, a maid from Gaochang, is an autopsy expert. These two ladies help Kaifeng Seven unravel bewildering cases. However, danger is lurking everywhere in Kaifeng Prefecture. When it is revealed that the emperor's heritage is questionable, Bao Zheng has to handle the most difficult case yet as he faces the dilemma of revealing the truth or abandoning his conscience for the sake of his country.