A doctor and his recently-deceased patient are reborn as twins to a famous Japanese musical idol and navigate the highs and lows of the Japanese entertainment industry as they grow up together through their lives.

In 2052, a Nobel Prize-winning neuroscientist develops a drug called Hapna — a cure-all that has the unexpected side-effect of causing death three years later. In response to this threat, a special force of agents—nicknamed "Lazarus"— is assembled to take on the malevolent Skinner.