The Autobots and Decepticons find themselves pulled by an unknown mastermind into the virtual realm of Cyberworld. Forced to compete in challenges to earn energon and gain strength, the trapped Transformers must battle the elements and each other to try and survive long enough to figure out who's behind it all.

On a cursed island ravaged by a strange plague called "the Malaise," a king commissions his alchemists to develop a cure to save his people from the disease... but the antidote turns the kingdom's inhabitants into monsters! The king decides to create an army using this formula, but the situation quickly spirals out of control.