A simple yet heartwarming story of a three-generation family, The Road Home portrays the love and conflicts between family members running a general hospital. It explores the lives of the grown-up children who each have their own problems to solve, and the way they cope with their aging parents.Yoo Min-soo is the eldest son of the hospital's CEO. His wife Jang Mi-ryung bears a child out of wedlock but raises it with maternal love.Hiro, a Japanese model, confesses his love for Ji-soo, Min-soo's sister. But Ji-soo must later come to grips with the secrets behind her birth.

The series revolves around Kim Jem Ma, a daughter who has strong desire to take revenge from her heartless mother, who left her father and sick brother in search of love and desire for her success.