The universe's woolly war machine, Bigfoot, is back in high-flying, foot-stomping action. When a band of thieving, intergalactic villains - led by the notorious outer space outlaw, Megalodon - start running roughshod, the super-sized Sasquatch is enlisted by Earth's surviving allies to infiltrate the gang and restore law and order to the cosmos. So, together with his newly-assigned partner, the untrustworthy astronaut, Holmes, 'Foot soars straight into the eye of the storm. Add to the mix a duplicitous commander who operates as mankind's last line of defense - but is secretly a centuries-old reincarnated witch, a tortured Dr. Frankenstein who's wracked with guilt over his missing monster's dire predicament, a traveling squad of hapless alien abductors, and the terrible team of Tickles the Clown, Crosscoe the Werewolf, Bartholomew the Man-Made Monster and the mighty Megalodon, and you've got all the ingredients for mad monster mayhem. And, like the marquee promises, eternal rivals Bigfoot and Megalodon WILL square-off and fight to the death. Sasquatch vs. Shark. Fist vs. Fin. With the survival of the whole universe hanging in the balance. It's Bigfoot vs. Megalodon 2.

In the aftermath of Earth’s nuclear destruction, scientist Jack Van Helsing - descendant of famed vampire hunter, Dr. Van Helsing - joins forces with a team of astronaut survivors. But, when their camp is ambushed by the rogue war machine, Xterminator, Van Helsing again finds himself lost in space. With no planet to call home, the whole universe is the arena for mankind’s wildest battle for survival!

Dangerous outlaw Xterminator is apprehended, but accepts a deal: find and return the galaxy's peacekeeper within 24 hours, or else he'll be destroyed.