In this campy screwball comedy, environmentalist Larry takes an experimental virility drug to woo back his wife Mary who's having an affair with Barry who works for Thierry who plans to destroy the remaining habitat of the endangered pocket mouse. Larry and Barry both take a double dose of the virility drug and when it makes them gay their entire world view changes. Barry resists and attempts ridiculous 'conversion' treatments; Larry discovers the joys of being a gay man. They both get what they want in the end.

During a business retreat, an epic earthquake hits Astoria Oregon, forcing Aaron to set out on foot to reach home, unsure if he'll survive the 725 mile journey and what he'll find at the end.