In the untamed West of Victorian-era America, a drifter takes a job as a barman in a small town. After a series of bizarre deaths, he soon finds himself the target of suspicion.

A pack of werewolves known as the Hell Hounds wage a shadow war against a fanatical order of werewolf hunters called the Silver Bullets. The Hounds and the Bullets now roam the country appearing to the outside world as rival biker gangs.

In pursuit of a gang of violent criminals, Officer Charlotte Briggs finds herself caught in twisted game of life and death. An abandoned missile facility deep in the Arizona desert becomes a labyrinthian house of horrors. Briggs must battle terrifying mutants and a sinister voice known only as the Overseer as she fights a life and death battle for survival.