Dr. Amy Larsen must navigate an unfamiliar world after a brain injury erases the last eight years of her life. She can rely only on her estranged 17-year-old daughter, whom she remembers as a 9-year-old, and a handful of devoted friends, as she struggles to continue practicing medicine, despite having lost nearly a decade of knowledge and experience.

On Halloween Eve, Britt and the kids she is babysitting have to survive the horror of serial killer Abner Honeywell, who is himself the traumatized son of B-movie horror legend "Natty Knocks".