In 1971, four women defy convention and join Mexico's first female police force, only to discover it's a publicity stunt to distract the media from a serial killer. As the body count grows, they make a pact to bring the killer to justice.

In 1985 Mexico City, a catastrophic earthquake buries thousands. A doctor with a dark past, a journalist chasing fame, and a family in distress risk their lives in rescue attempts. Their efforts become chances to change their own lives.

Alvaro, an optimistic young man falls in love with Carla, a girl who is in a mental clinic. In trying to help her, he learns that mental illness requires more than just a positive attitude to overcome.